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Of 307 publications retrieved, 67 randomized, controlled trials met the eligibility criteria and were included in this review (4 alogliptin, 8 linagliptin, 8 saxagliptin, 20 sitagliptin, and 27 vildagliptin trials).
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Traditionally, therapies for Non-Insulin dependent diabetes was dominated by relatively old and off- patent drugs primarily comprising (metformin) and sulfonylureas.
Kolterman OG, Kim DD, Shen L, Ruggles JA, Nielsen LL, Fineman MS, Baron AD 2005 Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus.
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Sitagliptin wurde im Oktober 2006 von der amerikanischen Arzneimittelzulassungsbehörde (FDA) sowohl für eine als auch für die Anwendung in Kombination mit oder zugelassen.
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Comparison of vildagliptin as an add-on therapy and sulfonylurea dose-increasing therapy in patients with inadequately controlled type 2 diabetes using metformin and sulfonylurea (VISUAL study): A randomized trial.
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